Many of the biblical stories take place in this region, hence why it is the "heartland" of the Jewish people.
Judea and Samaria (In Hebrew it is Yehudah v'Shomron) spans over the territory once designated by ancient Israeli Kingdoms. These names came about after the Assyrian conquest of the Northern Israelite Kingdom and the Southern Kingdom of Judah, circa 721 BCE. The Assyrians drove out the residents and through forced resettlement, occupying the former Kingdom of Israel with a group pf people named the Samaritans, of which the name "Samaria" is derived from. During the Roman period, the name of the Kingdom of Judah was Hellenized to Judea.